Classical descriptions of circadian interventions include sleep-wake cycles, light exposure and timing of activities. Recent findings in the field of chronobiology expand perspectives and potential interventions in cases in which weak or irregular zeitgebers (time signal givers) may be disrupting patients’ circadian rhythms and producing dysfunction in metabolism and mental health. These external signals could help reset internal biological clocks and correct the chronodisruption that underlies many metabolic and mental disorders. Although less explored, meal timing and time-restricted eating (TRE) are also powerful zeitgebers. Atypical depression has metabolic underpinnings that aren’t effectively addressed by conventional psychopharmacology and psychotherapeutic treatments. Often, atypical depression is characterized by an immuno-inflammatory profile and metabolic syndrome. TRE addresses these underlying pathophysiological processes, thereby improving both metabolic health and psychiatric symptomatology.